Different food types extract substances differently - aqueous foods mobilize hydrophilic compounds, acidic foods enhance metal extraction, alcoholic beverages solubilize specific additives requiring simulant selection matching intended use. Single-use overall migration testing in liquid simulants (A, B, C, D1) evaluates total substance transfer under conditions representing different food types following EU 10/2011 requirements. Simulant selection matches intended food contact - aqueous simulant A for water-based foods, acidic simulant B for foods below pH 4.5, alcoholic simulant C for beverages containing alcohol, and D1 for general fatty or oily foods. Gravimetric determination provides definitive measurement of migration levels ensuring compliance with regulatory limits of 10 mg/dm² or 60 mg/kg regardless of migrated substance identity. Critical for medical devices contacting various food types during clinical nutrition where simulant selection represents actual use, enteral feeding applications where nutritional formulations vary from aqueous to fatty compositions, and regulatory submissions requiring demonstrated compliance with food type-specific conditions. For devices contacting acidic nutritional formulations, simulant B testing reveals enhanced metal extraction that neutral simulants miss, while alcoholic simulant testing proves relevant for medical devices used with alcohol-containing medications or disinfectants. The multi-simulant approach ensures comprehensive assessment across intended uses, identifies worst-case migration conditions guiding material selection and specification setting, and supports risk assessment demonstrating safety regardless of food type variability. Manufacturing validation confirms materials achieve acceptable migration across relevant simulants, processing doesn't differentially affect migration in specific simulants suggesting material changes, and specifications account for simulant-dependent migration variations preventing surprises during regulatory testing.